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How dangerous is methotrexate? The dangers of daily dosing Taking methotrexate for as little as three days in a row is enough to cause serious consequences, including sepsis (infection of the blood) and death. Note that this is different to high-dose methotrexate in chemotherapy, where "rescue therapy" is used to prevent toxicity. How much does leflunomide cost? Leflunomide Medicare Coverage and Co-Pay Details - GoodRx. LEFLUNOMIDE is for rheumatoid arthritis. The lowest GoodRx price for the most common version of leflunomide is around $21.64, 91% off the average retail price of $242.09. Compare antirheumatics. Can methotrexate be taken on an empty stomach? It is important to take methotrexate exactly as directed by your doctor. Methotrexate should be taken on an empty stomach with a glass of water. вЂў For once daily dosing: If you miss a dose of methotrexate, take it as soon as you can if it is within 12 hours of the missed dose. Can you get Methotrexate over the counter? This includes over-the-counter pain medicine such as NSAIDs. Pain medicines can increase the effects of methotrexate, which can be bad for you. Don't get any vaccines (shots) while you are taking methotrexate. If you have stopped taking methotrexate, talk to your doctor to make sure that it's okay to get a vaccine.
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